Mechanism of Gattermann Reaction

Asked by Mahima A · 2 years ago

How does the mechanism of the Gattermann reaction work? Could someone break down the steps involved?

1 Answer

The mechanism of the Gattermann Reaction involves the following steps:

  1. Formation of the Formyl Cation: The HCN reacts with HCl to form the formyl cation (H+-C≡N).
  2. Activation of the Aromatic Ring: The aromatic compound reacts with the Lewis acid (AlCl3 or CuCl) which activates it towards electrophilic substitution.
  3. Electrophilic Attack: The formyl cation then attacks the activated aromatic ring, leading to the formation of an intermediate complex.
  4. Deprotonation: The intermediate complex loses a proton (H+) to form the final aromatic aldehyde product.

This stepwise mechanism helps in understanding how the formyl group is introduced into the aromatic ring, making the Gattermann Reaction a valuable tool in organic synthesis.

NEET Faculty · 2 years ago

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