Mechanism of Sandmeyer Reaction
Asked by Jai Gupta · 1 year ago
What is the Sandmeyer reaction and what is its mechanism?
1 Answer
The Sandmeyer reaction is a method to convert aromatic amines into aryl halides, cyanides, or thiocyanates. The mechanism involves:
1. Diazotization: The aromatic amine reacts with nitrous acid to form a diazonium salt.
2. Nucleophilic substitution: The diazonium salt reacts with Cu(I) salt to form an aryl radical.
3. Radical reaction: The aryl radical combines with the halide, cyanide, or thiocyanate to form the final product.
For example: ArNH2 → ArN2+ → Ar• → ArX (where X = Cl, Br, CN, or SCN)
1. Diazotization: The aromatic amine reacts with nitrous acid to form a diazonium salt.
2. Nucleophilic substitution: The diazonium salt reacts with Cu(I) salt to form an aryl radical.
3. Radical reaction: The aryl radical combines with the halide, cyanide, or thiocyanate to form the final product.
For example: ArNH2 → ArN2+ → Ar• → ArX (where X = Cl, Br, CN, or SCN)
NEET Faculty · 1 year ago
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