The primary cause of photorespiration is the competitive binding of which two molecules to the active site of RuBisCO?
The text highlights that 'RuBisCO also catalyses a wasteful oxygenation reaction' in addition to its role in $\text{CO}_2$ fixation. This 'oxygenation reaction' arises from the competition between $\text{CO}_2$ and $\text{O}_2$ for RuBisCO's active site.