Choose the correct electronic configuration which has the highest difference between first & second ionisation enthalpies.
The electronic configuration $1s^2 2s^2 2p^6 3s^2 3p^6 4s^1$ corresponds to a noble gas core configuration with one electron in the 4s orbital. The first ionization energy removes this 4s electron, which is relatively easy. However, the second ionization energy requires removing an electron from the stable, noble gas core, which is significantly more difficult. This results in a high difference between the first and second ionization enthalpies.