If for some reason the parietal cells of the gastric epithelium become partially non-functional, what is likely to happen?
Parietal or oxyntic cells present in mucosa of stomach secrete HCl and intrinsic factor (factor essential for absorption of vitamin B12). If these cells become partially non-functional, then HCl would not be secreted in adequate amounts, thus it would not allow the conversion of pepsinogen to pepsin which converts proteins into proteoses and peptones. (page-262).