Which of the following changes in chromosome number and DNA content occurs at Anaphase of mitosis in a diploid organism (2n chromosomes, 2C DNA content in G1)?
In G1, the cell has 2n chromosomes and 2C DNA. After S phase and until metaphase, the cell maintains 2n chromosomes (each with two chromatids) and 4C DNA. During anaphase, the centromeres split, and sister chromatids separate, moving to opposite poles. At this point, each chromatid is considered an individual chromosome. Therefore, temporarily, the chromosome number doubles to 4n, and the DNA content remains 4C in the entire cell during anaphase, before cytokinesis fully separates them.