The Ti plasmid, naturally found in Agrobacterium tumifaciens, is modified to be used as a cloning vector by:
While not explicitly stated in the provided excerpt about the modification of Ti plasmid, the text does mention that Agrobacterium delivers T-DNA to induce tumors. A 'better understanding... has generated knowledge to transform these tools of pathogens into useful vectors for delivering genes of interest to humans,' implying that the tumor-inducing capacity would be disarmed for safe use as a vector.