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If a haemophilic female who marries a normal male gives birth to a male child, then what are the chances of boy being normal? (a hypothetical situation but it won’t happen practically)

50 %

25%

75%

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Explanation

Concept - NCERT Page No. 89

If the mother is haemophilic. Her genotype will be X^hX^h( as haemophilia is X linked recessive disorder). And male child can inherit only X chromosome from mother, so he will inherit X^h from his mother. Now for being haemphilic, one has to get another X^h but for male another sex chromosome will be Y, Here comes the Hemizygous situation. So, in any case, male is going to be haemophilic. No chances of being normal.i.e. 0% chances of male being normal in this situation.

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In ABO blood grouping how many genotypes show co-dominance?

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Explanation

NCERT Page No. 77

In ABO blood grouping, I^AI^B genotype shows co-dominance.

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Which of the following is the sex linked disease?

Sickle cell anaemia

Haemophilia

Cystic fibrosis

Phenylketonuria

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Explanation

NCERT Page No. 89

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Mendelian disorders are caused by

Mutation in the single chromosome

Mutation in the single gene

Polyploidy

Aneuploidy

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Explanation

NCERT Page No. 88

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Boy born to a physically normal couple has been diagnosed with a genetic disorder, this could be

Y- linked trait.

Autosomal dominant trait

X- linkeddominant trait

X- linked recessive trait

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Explanation

NCERT Page No. 89

Normal mother has to be a carrier for it as the male progeny inherits the X chromosome from his mother so only the case of X- linked recessive will support the diseased male (hemizygous condition refer to logic of Q. 80).

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Which of the following disorder is associated with Queen Victoria?

Sickle cell anaemia

Haemophilia

Huntington's Disease

Myotonic dystrophy

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Explanation

NCERT Page No. 89

Recessive disorders will be transmitted only if both the parents are carriers or diseased.

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Which of the following is least probable?

Female child with Sickle cell anaemia

Male child with haemophilia

Carrier female for haemophilia

Female child with haemophilia

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Explanation

NCERT Page No. 89

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Elongated sickle like structure of RBC is produced by

Platelets deposition on the outer surface of RBC

Reduced surface tension

Polymerisation of mutant haemoglobin under high oxygen tension.

Polymerisation of mutant haemoglobin under low oxygen tension.

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Explanation

NCERT Page No. 89

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Sickle cell anaemic person will have

Abnormal beta globin chain and sickle shaped RBC

Normal beta globin chain and sickle shaped RBC

Abnormal beta globin chain and biconcave RBC

Normal beta globin chain and biconcave RBC

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Explanation

NCERT Page No. 89

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Mental retardation is associated with

Klinefelter’s syndrome

Haemophilia

Cystic fibrosis

Phenylketonuria

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Explanation

NCERT Page No. 90

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