Trace amounts of hormones can elicit significant effects because:
Though not explicitly stated as 'why' trace amounts are effective in a single sentence, the text explains that hormones 'act as intercellular messengers and are produced in trace amounts' and 'produce their effects on target tissues by binding to specific proteins called hormone receptors... Hormone-Receptor complex formation leads to certain biochemical changes in the target tissue.' This binding and subsequent biochemical cascade allows even trace amounts to have a significant effect.